Forsyth is the world’s leading independent research organization dedicated to improving oral and overall health. Our portfolio includes basic, translational, and clinical research, as well as active technology transfer and corporate collaboration efforts. With expertise in oral health, the dynamic interface between humans and our microbiome, and the interactions among different systems of the body, Forsyth researchers are dedicated to promoting health and preventing disease.

Forsyth is an incubator of firsts.

We developed the first local antibiotic to treat gum disease and sequenced the first oral bacterial genome. We made the discovery that cavities are the result of bacterial infection and identified the specific bacteria to blame. From our research and technology transfer to our local and global pediatric and public health outreach, Forsyth has always been on the front lines of oral health.

Key areas of investigation include:

  • Microbiology and the microbiome 
  • Immunology and inflammation
  • Tooth formation and evolution
  • Clinical and translational research

Other areas of Forsyth research expertise include:

  • Human genomics
  • Bioinformatics
  • Epidemiology
  • Biostatistics
  • Public health
  • Systems biology
  • Saliva-based diagnostics

Scientists at Forsyth work to increase knowledge about both oral and overall health, with an emphasis on integrating laboratory work and clinical research. Many of our researchers use the mouth as a portal to learn more about the body. For example, how does inflammation in the mouth contribute to systemic diseases such as diabetes and heart disease? Other scientists investigate how bacteria in and on the human body, collectively known as the microbiome, play a role in health and disease—from cavities to pneumonia.  

Forsyth has more than 30 principal investigators plus dozens of research associates, students, and post-doctoral fellows, creating a robust scientific ecosystem conducive to interdisciplinary collaboration.

Forsyth also partners with a range of academic institutions, hospitals, other independent research institutes, biotech and pharmaceutical companies, and start-ups. These interactions provide access to internationally acclaimed collaborators, graduate students and postdoctoral fellows, specialized facilities, and a wide range of technical and theoretical expertise.

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