Forsyth was founded as a dental infirmary for vulnerable children and has evolved over the past 100 years to become a world-renowned research institution. Our research portfolio has changed, but the underlying motivation of the institute has remained steadfast—to advance human health and overall wellness through biomedical research, public health outreach, and clinical innovation.

Our scientists offer a broad range of expertise, and the institute has particular strength in these key areas of investigation:

Clinical and translational research

The mission of the Center for Clinical and Translational Research (CCTR) is to translate innovative and significant research questions into clinical use. Forsyth’s CCTR team can test basic science ideas or new discoveries chair-side in a clinical setting, or explore human disease pathways bench-side in the lab.

Microbiology and the microbiome

The human microbiome is a major frontier of biomedical research exploration. Scientists at Forsyth are studying the oral and nasal microbiomes to gain a deeper understanding of tooth decay, overall health, and risks for certain infections.

Immunology and inflammation

Scientists are beginning to understand the major role inflammation plays in overall health. One area of research at Forsyth focuses on a new class of inflammation-resolving compounds that not only alleviate inflammation, but also help regenerate tissues, fight bone loss, and slow the progression of heart disease.

Teeth and mineralized tissue biology

Currently, there is no cellular mechanism for repairing enamel after tooth eruption. Forsyth scientists are examining how genetic background and interaction with the oral environment changes the composition of tooth enamel, with the goal of developing novel mechanisms of tooth repair.