Sjӧgren’s syndrome is a prevalent and systemic autoimmune disorder characterized by immune system attacking self-salivary and lacrimal glands, leading to xerostomia and keratoconjunctivitis sicca as major clinical manifestations. This disease also can cause an increased incidence of dental diseases, as well as various systemic complications that significantly reduce the quality of life. To date, there is no effective intervention available for Sjӧgren’s syndrome.
Jing Zhou is interested in innate immune cell-mediated pathogenesis of Sjögren’s syndrome. She is conducting studies to determine the precise in vivo role of innate immune cells in the development and persistence of Sjögren’s syndrome and dissect the underlying molecular and cellular mechanisms using different mouse models as well as human samples of this disease. Her research also focuses on immune cell-mediated dental and periodontal diseases in the context of Sjögren-like disorder. Zhou hopes that her research will provide crucial knowledge and basis for the development of effective cell-targeted therapies against Sjögren’s syndrome as well as other autoimmune disorders that share similarities in the pathogenic mechanisms with Sjögren’s syndrome.
Jilin University, China, PhD, 2009, Immunology